Important Questions For D.pharm 2nd Year SUMMER- 2022 ( Pharmaceutical Chemistry - II)

                                      Pharmaceutical Chemistry - II (0812)

1. a) - Give structure and method of numbering for-

Isoquinoline ,Pyridine,Thiazole,Piperidine, Acridine, Furan, Imidazole,Benzimidazole,Acridine,Quinoline,

Pyrazole,Isoquinoline,Indole,Phenothiazine,  Piperazine,

Pyrimethamine,Sulphadiazine,Oxazole,Pyrimidine,Thiophene,

Isoxazole,Benzodiazepine,

b) -  Draw structure from given chemical name-

2,6-diamino acridine

N-acetyl sulfanilamide  , 

2-Bromo, 2- Chloro-1, 1 , 1-trifluoroethane,   

4-chloro N-furfuryl 5-sulphamoyl anthranilic acid, 

Ethyl – P- amino benzoate, 

4-butyl 1,2-diphenyl Pyrazolidine-3,5-dione

7-Chloro-1,3-dihydro-1-methyl-5-phenyl-1,4-benzodiazepine-2-one

1-(Isopropyl amino)-3-(1-naphthyloxy)propan-2-ol

6 (2-phenoxy acetamido) Penicillanic acid.

N1 -Acetylsulfanilamide sodium

5-(4-Chlorophenyl)-6-ethylpyrimidine-2,4-diamine.

c)- Write name and structure of the drug containing following heterocycle-

Pyridazine(Drug Name -Sulfamethoxy pyridazine, Hydralazine)   , 

Barbituric acid(Phenobarbitone) , 

Penam (Penicilline-G, Penicilline-V, Ampicillin)

Acridine (Proflavine)

Pyridine(Isoniazid,Nikethamide)

Indole(- Indomethacin)

Benzodiazepine(Diazepam)

Quinoline(Chloroquine)

Isoxazole(Sulphamethoxazole)

Phenothiazine(Chlorpromazine)

Xanthine(Caffeine)

Pyrimidine(Pyrimethamine)

d)Define/Explain the following terms with example-

Cardiotonic,Vasodilator,Antidepressants ,Diuretics,Antineoplastics,Anti-coagulants,Antiseptic and Disinfectants,Antihypertensives,Antihistaminic,Neuroleptic,Analgesic,Coagulants,Tranquilizers

Lipid lowering agent,Haemostatics,Hypoglycemic agents,Antipyretics,Antianginal ,

e)Give two brand names of following drugs -

Paracetamol: Tylenol, Calpol, panadol, crocin, metacin, valadol, paldesic, Dolo 

Ibuprofen- Ibugesic, Ibuspan SR, Ibuflamar, Brufen

Metronidazole: Aristogyl, Flagyl, Metrogyl, Aldezol, Unimezol 

Streptomycin- Ambistryn inj, Cipstryn inj, Merstryp inj.

Salbutamol: Ashtalin, Respira, Salbetol, Ambrodil, Sobrex,, Salbuton, Asthasol

Phenformin : Sucronase, Bislim, Diaformin 

Tetracyclin: Achromycin, Enterocyclin, Cadicyclin 

Aspirin: Aspro, Anacin, Coldarin, Powerin, Mejorol, codopyrin

Metformin: Dideta SR, Formin, Metchek, Forminal 

Metronidazole: Aristogyl, Flagyl, Metrogyl, Aldezol, Unimezol

Furosemide: Fru, Lasix, Frusenex 

Diazepam: Calmpose, Valium, Elcion-CR

Propranolol: Ciplar, Inderal, Corbeta, Betacap TR

Diphenhydramine: Benadryl Syrup, Bronolax Syrup, Abcof Syrup etc

Cotrimoxazole : Ciplin, Trisulfose, Tprim forte, Bactrim, Sepmax, Oriprim, Tabrol

Ampicillin : Roscillin, Orcillin, Ampilin, Bacipen, Zycillin, Biocilin, 

Mebendazole : Mebex, Mebidex, Mebenth, Lupimeb, Wormin,

f)In what dosage form the following drugs are given - 

(i) Insulin : 1) Insulin Injection, 

                   2) Insulin Injection Biphasic 

                   3) Neutral Insulin Injection 

                   4) Globin zinc Insulin Injection 

                   5) Isophane Insulin Injection 

                   6) Protamin zinc Insulin Injection 

                   7) Insulin zinc Suspension

(ii) Mebendazole: 1) Mebendazole Tablet 

                             2) Mebensazole Syrup

(iii) Procaine : Procaine Injection

      Tolnaftate  : Tolnaftate Cream 

                           Tolnaftate gel 

                            Tolnaftate powder 

                             Tolnaftate topical aerosol powder 

                            Tolnaftate topical solution

g)Classify following drug with example -

antitubercular drug, 

Sympathomimetic agents,

local anaesthetics

anticholinergic

Cholinergic drugs

h)Write Structure Of The Following Organic group -

Anilino,Cyano,Isopropyl, Benzoyl, Aniline , Benzyl, Vinyl, Amino ,Acetyl,Isopropyl,Allyloxy,

Amido,Guanidinyl,Guanidino,Formyl,Carbamoyl,Diethylamino,Sulphamoyl,Dimethylamino,

i)Name the drug present in following brands-

                     (i) Mebex: Mebendazole 

                     (ii) Valium: Diazepam 

                     (iii) Corex: Chlorpheniramine maleate and Codeine phosphate

                            Ecosprin- Aspirin 

                     (ii)  Stemetil- Prochlorperazine maleate  

                     (iii) Valium – Diazepam

j) Write uses of the following-

Nikethamide,Thiambutosine,Benzocaine,Thyroxin,Thrombin,Paracetamol,Proflavin,5-fluorouracil,Warfarin,Analgin,Promethazine,

k)Write Structure  & Uses Of Following Drug-

 Ethambutol,Phenbutazone,Atropine,Caffeine,Haloperidol,DEC,Propranolol,Chloroquine,Isoniazid, Procaine,Neostigmine,Furosemide,Mannitol,D.E.C.,Isoniazid,Penicillin V,Sulfacetamide,Chlorocresol,

l)Give the stability – storage condition of -

Heparin,Insulin,Thrombin,Diethyl ether,Acetylcholine,Ibuprofen

m)Write uses of-

Evan’s blue,Congo red,Indigocarmine,Iopanoic acid,Fluorescein sodium,Nystatin

n)Define vitamins. Write the importance of vitamin A ?

o)Write the names of four fat soluble vitamins ?

2.aNSWER THE FOLLOWING